Many diseases appear to be caused by the misregulation of protein maintenance. Such
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …

Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal
models of neurodegenerative diseases. Such results were mainly associated with the …

Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a
wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's …

Although, current medications for Parkinson's disease can control and relief symptoms of the
disease efficiently, they are unable to either prevent progression of the disease or maintain …

Amyloid β (Aβ) is involved in the etiology of Alzheimer's disease (AD) and may contribute to
cognitive deficits by increasing internalization of ionotropic glutamate receptors. Striatal …

Experimental data indicate that transneuronal propagation of abnormal protein aggregates
in neurodegenerative proteinopathies, such as sporadic Alzheimer's disease (AD) and …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to
interdict disease signs and symptoms. In recent years this need was met through therapeutic …

Alpha-synuclein (aSyn) is the main component of proteinaceous inclusions known as Lewy
bodies (LBs), the typical pathological hallmark of Parkinson's disease (PD) and other …