Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies

NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment and prevent …

NA Sharif - Experimental eye research, 2023 - Elsevier
A multitude of pharmacological compounds have been shown to lower and control
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …

[HTML][HTML] Degeneration of retina-brain components and connections in glaucoma: Disease causation and treatment options for eyesight preservation

NA Sharif - Current Research in Neurobiology, 2022 - Elsevier
Eyesight is the most important of our sensory systems for optimal daily activities and overall
survival. Patients who experience visual impairment due to elevated intraocular pressure …

Discovery to launch of anti-allergy (Emadine; Patanol/Pataday/Pazeo) and anti-glaucoma (Travatan; Simbrinza) ocular drugs, and generation of novel …

NA Sharif - ACS Pharmacology & Translational Science, 2020 - ACS Publications
The eye and eyesight are exquistly designed and are precious, and yet we often take them
for granted. Good vision is critical for our long-term survival and for humanity's enduring …

Neuropathology and therapeutics addressing glaucoma, a prevalent retina-optic nerve-brain disease that causes eyesight impairment and blindness

NA Sharif - OBM Neurobiology, 2022 - lidsen.com
Glaucomatous optic neuropathy (GON) associated with different forms of glaucoma and
chronic ocular hypertension (cOHT) is characterized by progressive loss of retinal ganglion …

[HTML][HTML] Concordance of objectively detected retinal nerve fiber bundle defects in en face OCT images with conventional structural and functional changes in …

R Cheloni, J Denniss - Ophthalmology Glaucoma, 2023 - Elsevier
Purpose To assess how objectively detected defects in retinal nerve fiber bundle (RNFB)
reflectance on en face OCT images relate to circumpapillary retinal nerve fiber layer …

Visual field asymmetries in responses to ON and OFF pathway biasing stimuli

MTW Scott, A Yakovleva, AM Norcia - bioRxiv, 2024 - biorxiv.org
Recent reports suggest the ON and OFF pathways are differentially susceptible to selective
vision loss in glaucoma. Thus, perimetric assessment of ON-and OFF-pathway function may …

[PDF][PDF] Current Research in Neurobiology

R Hartig, PC Klink, Z Polyakova - Current Research in Neurobiology, 2023 - pure.knaw.nl
As science and technology evolve, there is an increasing need for promotion of international
scientific exchange. Collaborations, while offering substantial opportunities for scientists and …

Effects of glaucoma on detection and discrimination of image blur

HA Bham, J Denniss - Ophthalmic and Physiological Optics, 2022 - Wiley Online Library
Purpose Blur is one of the most commonly reported visual symptoms of glaucoma, but it is
not directly measured by current clinical tests. We aimed to investigate the effects of …

Inflammatory and immunological aspects of glaucoma, optic neuritis, and neuromyelitis optica impacting eyesight

NA Sharif - Translational Neuroimmunology, Volume 7, 2023 - Elsevier
Like many human systemic and central nervous system disorder, several eye diseases stem
from or involve an aberrant immune system. Since inflammation and the immune system are …