[HTML][HTML] Pharmacological treatment of vascular dementia: a molecular mechanism perspective

H Kuang, ZF Zhou, YG Zhu, ZK Wan, MW Yang… - Aging and …, 2021 - ncbi.nlm.nih.gov
Vascular dementia (VaD) is a neurodegenerative disease, with cognitive dysfunction
attributable to cerebrovascular factors. At present, it is the second most frequently occurring …

Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia-and addiction-relevant features: The RHA vs. RLA rats

A Fernández-Teruel, I Oliveras, T Cañete… - Neuroscience & …, 2021 - Elsevier
Abstract The Roman High-(RHA) and Low-(RLA) avoidance rat lines/strains were generated
through bidirectional selective breeding for rapid (RHA) vs. extremely poor (RLA) two-way …

Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior

B Elfving, HK Müller, I Oliveras, TB Østerbøg… - Progress in Neuro …, 2019 - Elsevier
Schizophrenia is considered a neurodevelopmental disorder. Recent reports relate synaptic
alterations with disease etiology. The inbred Roman High-(RHA-I) and Low-(RLA-I) …

Neuroprotective effects of adenosine A1 receptor signaling on cognitive impairment induced by chronic intermittent hypoxia in mice

Y Zhang, H Cao, X Qiu, D Xu, Y Chen… - Frontiers in cellular …, 2020 - frontiersin.org
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a breathing disorder associated
with cognitive impairment. However, the mechanisms leading to cognitive deficits in OSAHS …

Identification of the SNARE complex mediating the exocytosis of NMDA receptors

Y Gu, RL Huganir - Proceedings of the National Academy of …, 2016 - National Acad Sciences
In the central nervous system, NMDA receptors mediate excitatory neurotransmissions and
play important roles in synaptic plasticity. The regulation of NMDA receptor trafficking is …

Omega‐3 fatty acids regulate plasticity in distinct hippocampal glutamatergic synapses

S Aryal, S Hussain, CA Drevon… - European Journal of …, 2019 - Wiley Online Library
Dietary omega‐3 fatty acids accumulate and are actively retained in central nervous system
membranes, mainly in synapses, dendrites and photoreceptors. Despite this selective …

Postsynaptic SNARE proteins: role in synaptic transmission and plasticity

MP Madrigal, A Portalés, MP SanJuan, S Jurado - Neuroscience, 2019 - Elsevier
Soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins
mediate membrane fusion events in eukaryotic cells. Traditionally recognized as major …

Floralozone improves cognitive impairment in vascular dementia rats via regulation of TRPM2 and NMDAR signaling pathway

Y Yin, Y Liu, M Zhu, H Wang, Y Qiu, G Wan, P Li - Physiology & Behavior, 2022 - Elsevier
Vascular dementia (VD) is the second largest type of dementia after Alzheimer's disease. At
present, the pathogenesis is complex and there is no effective treatment. Floralozone has …

mTORC1 is a local, postsynaptic voltage sensor regulated by positive and negative feedback pathways

F Niere, KF Raab-Graham - Frontiers in cellular neuroscience, 2017 - frontiersin.org
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) serves as a
regulator of mRNA translation. Recent studies suggest that mTORC1 may also serve as a …

[HTML][HTML] Synapse-specific changes in arc and BDNF in rat hippocampus following chronic temporal lobe epilepsy

DL Egbenya, S Hussain, YC Lai, AE Anderson… - Neuroscience …, 2023 - Elsevier
Expression of immediate early genes (IEGs) in the brain is important for synaptic plasticity,
and probably also in neurodegenerative conditions. To understand the cellular mechanisms …