ABSTRACT Introduction Traumatic brain injuries (TBIs) impact the breadth of society and
remain without any approved pharmacological treatments. Despite successful Phase II …

Cerebral ischaemia is implicated in poor outcome after brain injury, and is a very common
post-mortem finding. The inability of the brain to store metabolic substrates, in the face of …

Acidosis is among the least studied secondary injury mechanisms associated with
neurotrauma. Acute decreases in brain pH correlate with poor long‐term outcome in patients …

Acid-sensing ion channel 1a (ASIC1a) promotes neuronal damage during pathological
acidosis. ASIC1a undergoes a process called steady-state desensitization in which …

Tissue acidosis is an important secondary injury process in the pathophysiology of traumatic
spinal cord injury (SCI). To date, no studies have examined the role of proton extrusion as …

Objective To perform a systematic review on commonly measured cerebral microdialysis
(CMD) analytes and their association to:(A) patient functional outcome,(B) neurophysiologic …

There is growing debate over the value of intensive insulin therapy (IIT) in critically ill
patients. Available trials have been performed in general medical or surgical intensive care …

Glial fibrillary acidic protein (GFAP) is a well-established astrocytic biomarker for the
diagnosis, monitoring and outcome prediction of traumatic brain injury (TBI). Few studies …

Introduction The optimal blood glucose target following severe traumatic brain injury (TBI)
must be defined. Cerebral microdialysis was used to investigate the influence of arterial …

The voltage-gated proton channel Hv1 is a newly discovered ion channel that is highly
conserved among species. It is known that Hv1 is not only expressed in peripheral immune …