Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Membrane electroporation and electropermeabilization: mechanisms and models

T Kotnik, L Rems, M Tarek… - Annual review of …, 2019 - annualreviews.org
Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient
increase in their plasma membrane permeability, allowing transmembrane transport of …

Emerging mechanisms and targeted therapy of ferroptosis in cancer

H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang… - Molecular Therapy, 2021 - cell.com
Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …

Anti-fungal efficacy and mechanisms of flavonoids

MS Al Aboody, S Mickymaray - Antibiotics, 2020 - mdpi.com
The prevalence of fungal infections is growing at an alarming pace and the pathogenesis is
still not clearly understood. Recurrence of these fungal diseases is often due to their …

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

H Feng, BR Stockwell - PLoS biology, 2018 - journals.plos.org
Ferroptosis is a cell death process driven by damage to cell membranes and linked to
numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is …

The role of taurine in mitochondria health: more than just an antioxidant

CJ Jong, P Sandal, SW Schaffer - Molecules, 2021 - mdpi.com
Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in
excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first …

[HTML][HTML] Lipid peroxidation in cell death

MM Gaschler, BR Stockwell - Biochemical and biophysical research …, 2017 - Elsevier
Disruption of redox homeostasis is a key phenotype of many pathological conditions.
Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as …

Plasma membrane integrity in health and disease: significance and therapeutic potential

C Dias, J Nylandsted - Cell discovery, 2021 - nature.com
Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

Iron and ferroptosis: A still ill‐defined liaison

S Doll, M Conrad - IUBMB life, 2017 - Wiley Online Library
Ferroptosis is a recently described form of regulated necrotic cell death, which appears to
contribute to a number of diseases, such as tissue ischemia/reperfusion injury, acute renal …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …