Developing TRAIL/TRAIL death receptor-based cancer therapies

X Yuan, A Gajan, Q Chu, H Xiong, K Wu… - Cancer and Metastasis …, 2018 - Springer
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF superfamily that can initiate the apoptosis pathway by binding to its associated death …

Natural killer cell response to chemotherapy-stressed cancer cells: role in tumor immunosurveillance

A Zingoni, C Fionda, C Borrelli, M Cippitelli… - Frontiers in …, 2017 - frontiersin.org
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic
development, growth, and metastatic dissemination in a process called cancer …

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes

L Zhao, B Zhang - Scientific reports, 2017 - nature.com
Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients.
The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood …

Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene

T Jiang, W Sun, Q Zhu, NA Burns… - Advanced Materials …, 2014 - pmc.ncbi.nlm.nih.gov
Graphical abstract A cellular protease-mediated graphene-based nanosystem is developed
for co-delivery of a membrane-associated cytokine (TRAIL) and an intracellular-acting small …

Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) contributes to interferon γ–dependent natural killer cell protection from tumor metastasis

MJ Smyth, E Cretney, K Takeda, RH Wiltrout… - The Journal of …, 2001 - rupress.org
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is expressed by in vitro
activated natural killer (NK) cells, but the relevance of this observation to the biological …

Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and-independent pathways

A Suliman, A Lam, R Datta, RK Srivastava - Oncogene, 2001 - nature.com
Tumor necrosis (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF
family of cytokines that promotes apoptosis. TRAIL induces apoptosis via death receptors …

Doxorubicin-loaded human serum albumin nanoparticles surface-modified with TNF-related apoptosis-inducing ligand and transferrin for targeting multiple tumor …

S Bae, K Ma, TH Kim, ES Lee, KT Oh, ES Park, KC Lee… - Biomaterials, 2012 - Elsevier
Human serum albumin (HSA) nanoparticles (NPs) surface modified with tumor necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL) and transferrin, and containing …

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

CS Mitsiades, SP Treon, N Mitsiades… - Blood, The Journal …, 2001 - ashpublications.org
Multiple myeloma (MM) remains incurable and novel treatments are urgently needed.
Preclinical in vitro and in vivo evaluations were performed to assess the potential …

Research development on anti-microbial and antioxidant properties of camel milk and its role as an anti-cancer and anti-hepatitis agent

MZ Khan, J Xiao, Y Ma, J Ma, S Liu, A Khan, JM Khan… - Antioxidants, 2021 - mdpi.com
Camel milk is a rich source of vitamin C, lactic acid bacteria (LAB), beta-caseins and milk
whey proteins, including lactoferrin, lysozyme, lactoperoxidase, alpha-lactalbumin and …

Apoptosis regulators and their role in tumorigenesis

M Zörnig, AO Hueber, W Baum, G Evan - Biochimica et Biophysica Acta …, 2001 - Elsevier
It has become clear that, together with deregulated growth, inhibition of programmed cell
death (PCD) plays a pivotal role in tumorigenesis. In this review, we present an overview of …