Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-
family interactions makes it challenging to predict cell fate via standard molecular biology …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

Nanoparticles that functionally mimic the activity of metal‐containing enzymes (metallo‐
nanozymes) are of therapeutic importance for treating various diseases. However, it is still …

Mitochondria participate in apoptosis through a range of mechanisms that vary between
vertebrates and invertebrates. In vertebrates, they release intermembrane space proteins …

In stressed cells, apoptosis ensues when Bcl-2 family members Bax or Bak oligomerize and
permeabilize the mitochondrial outer membrane. Certain BH3-only relatives can directly …

The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the
1980s. Since then, significant in-roads have been made in identifying the multiple members …