Advances in molecular biology have revolutionized the use of messenger RNA (mRNA) as a
therapeutic. The concept of nucleic acid therapy with mRNA originated in 1990 when Wolff …

The first leptospiral recombinant vaccine was developed in the late 1990s. Since then,
progress in the fields of reverse vaccinology (RV) and structural vaccinology (SV) has …

Leptospirosis is a quintessential one health disease of humans and animals caused by
pathogenic spirochetes of the genus Leptospira. Intra-and interspecies transmission is …

Introduction Leptospirosis is a worldwide zoonosis caused by pathogenic and virulent
species of the genus Leptospira, whose pathophysiology and virulence factors remain …

Leptospirosis is an archetypal One Health problem as described in the companion Currents
in One Health article in the October 2022 issue of the Journal of the American Veterinary …

Bovine leptospirosis has as main causative agents Leptospira spp. from Sejroe serogroup.
Vaccination is a crucial step to control this infection. The use of conserved proteins among …

Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival
mechanisms during stress conditions. In regular environmental conditions, the antitoxin …

We investigated seroprevalence and factors associated with Leptospira spp. infections in
humans in rural Northern Germany. Sera of 450 participants were tested for leptospira …

Leptospirosis is a neglected tropical disease that remains potentially life threatening and
hard to diagnose. Climate change combined with overlapping reservoir and human habitats …

Background Leptospirosis is a priority zoonotic disease in Kenya, but an in-depth review of
its presence in humans, animals and the environment is lacking. Therefore, we conducted …