Systems, methods, and apparatuses to image a sample for biological or chemical analysis

MT Reed, E Williamson, B Crane, P Leung… - US Patent …, 2015 - Google Patents
Related US Application Data filed on Jan. 10, 2011, provisional application No. 61/431,439,
filed on Jan. 11, 2011, provisional appli cation No. 61/431,440, filed on Jan. 11, 2011, provi …

Single cell bar-coding for antibody discovery

F Vigneault, AW BRIGGS - US Patent 9,816,088, 2017 - Google Patents
G01N33/5008—Chemical analysis of biological material, eg blood, urine; Testing involving
biospecific ligand binding methods; Immunological testing involving human or animal cells …

Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays

F Barany, G Barany, RP Hammer, M Kempe… - US Patent …, 2005 - Google Patents
The present invention describes a method for identifying one or more of a plurality of
Sequences differing by one or more Single base changes, insertions, deletions, or …

Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions

F Barany, M Lubin, G Barany, RP Hammer - US Patent 7,364,858, 2008 - Google Patents
The present invention relates to a method for identifying a target nucleotide sequence. This
method involves forming a ligation product on a target nucleotide sequence in a ligase …

Method and apparatus for performing large numbers of reactions using array assembly with releasable primers

TM Brennan, F Chatelain, M Berninger - US Patent 6,632,641, 2003 - Google Patents
5,545,531. A* 8/1996 Rava et al. WO WO 98/21221 5/1998 5,545,568 A 8/1996
Ellman....................... 436/518 WO WO 98/22487 5/1998 5,556,749 A 9/1996 Mitsuhashi et …

Microarray fabrication system and method

MS Bowen, KL Gunderson, S Lin… - US Patent …, 2014 - Google Patents
A microarray is designed capture one or more molecules of interest at each of a plurality of
sites on a substrate. The sites comprise base pads, such as polymer base pads, that …

Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof

Y Liu, L Li, P Ren - US Patent 10,646,488, 2020 - Google Patents
(57) ABSTRACT 3,702,849 A 3,752,660 A 4,439,606 A 4,649,219 A 4,656,181 A 4,861,760
A 4,911,920 A 5,010,175 A 5,033,252 A 5,052,558 A 5,212,162 A 5,288,514 A 5,323,907 A …

Methods for generating amplified nucleic acid arrays

KL Gunderson, F Steemers - US Patent App. 11/943,554, 2008 - Google Patents
The present invention relates to methods for generating an array of amplified nucleic acid
sequences. The methods can utilize amplicons that form nucleic acid balls that can be …

Scanning of biological samples

M Blumenfeld, JJ Talghader, MA Sanders… - US Patent …, 2005 - Google Patents
An image detection apparatus comprises a light source and a holding apparatus adapted to
hold a substrate on which a biological sample may be mounted. Light from the light source …

Imaging of biological samples using electronic light detector

M Blumenfeld, MA Sanders, JJ Talghader… - US Patent …, 2006 - Google Patents
(57) ABSTRACT A system and method using an electronic light detector array, eg, a CCD or
a CMOS-based detector array, is used to acquire a visual image of a biological sample that …