The dormant blood microbiome in chronic, inflammatory diseases
Blood in healthy organisms is seen as a 'sterile'environment: it lacks proliferating microbes.
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …
L-form bacteria, chronic diseases and the origins of life
J Errington, K Mickiewicz… - … Transactions of the …, 2016 - royalsocietypublishing.org
The peptidoglycan cell wall is widely conserved across the bacterial domain, suggesting that
it appeared early in the evolution of bacteria. It is normally essential but under certain …
it appeared early in the evolution of bacteria. It is normally essential but under certain …
[HTML][HTML] Excess membrane synthesis drives a primitive mode of cell proliferation
The peptidoglycan cell wall is a hallmark of the bacterial subkingdom. Surprisingly, many
modern bacteria retain the ability to switch into a wall-free state called the L-form. L-form …
modern bacteria retain the ability to switch into a wall-free state called the L-form. L-form …
[HTML][HTML] Lysozyme counteracts β-lactam antibiotics by promoting the emergence of L-form bacteria
Y Kawai, K Mickiewicz, J Errington - Cell, 2018 - cell.com
Summary β-lactam antibiotics inhibit bacterial cell wall assembly and, under classical
microbiological culture conditions that are generally hypotonic, induce explosive cell death …
microbiological culture conditions that are generally hypotonic, induce explosive cell death …
General principles for the formation and proliferation of a wall-free (L-form) state in bacteria
The peptidoglycan cell wall is a defining structural feature of the bacterial kingdom.
Curiously, some bacteria have the ability to switch to a wall-free or 'L-form'state. Although …
Curiously, some bacteria have the ability to switch to a wall-free or 'L-form'state. Although …
Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis
GS Dobihal, YR Brunet, J Flores-Kim, DZ Rudner - elife, 2019 - elifesciences.org
Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from
osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge …
osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge …
Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics
The peptidoglycan cell wall is an essential structure for the growth of most bacteria.
However, many are capable of switching into a wall-deficient L-form state in which they are …
However, many are capable of switching into a wall-deficient L-form state in which they are …
The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis
Most bacteria contain both eukaryotic-like Ser/Thr kinases (eSTKs) and eukaryotic-like
Ser/Thr phosphatases (eSTPs). Their role in bacterial physiology is not currently well …
Ser/Thr phosphatases (eSTPs). Their role in bacterial physiology is not currently well …
Cell growth of wall-free L-form bacteria is limited by oxidative damage
The peptidoglycan (PG) cell wall is a defining feature of the bacterial lineage and an
important target for antibiotics, such as β-lactams and glycopeptides. Nevertheless, many …
important target for antibiotics, such as β-lactams and glycopeptides. Nevertheless, many …
Crucial role for membrane fluidity in proliferation of primitive cells
R Mercier, P Domínguez-Cuevas, J Errington - Cell reports, 2012 - cell.com
The cell wall is a defining structural feature of the bacterial subkingdom. However, most
bacteria are capable of mutating into a cell-wall-deficient" L-form" state, requiring …
bacteria are capable of mutating into a cell-wall-deficient" L-form" state, requiring …