Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

The faithful DNA replication is a critical event for cell survival and inheritance. However,
exogenous or endogenous sources of damage challenge the accurate synthesis of DNA …

Deubiquitinases (DUBs) are involved in various cellular functions. They deconjugate
ubiquitin (UBQ) from ubiquitylated substrates to regulate their activity and stability. Studies …

Synthesis and maturation of Okazaki Fragments is an incessant and highly efficient
metabolic process completing the synthesis of the lagging strands at replication forks during …

DNA is constantly exposed to a wide variety of exogenous and endogenous agents, and
most DNA lesions inhibit DNA synthesis. To cope with such problems during replication …

Ubiquitination is an essential eukaryotic post-translational modification that regulates
various cellular processes. The removal of ubiquitin from its target protein is catalyzed by …

Proliferating cell nuclear antigen (PCNA) is a crucial eukaryotic replication accessory factor
in the regulation of DNA synthesis, which is always used as a proliferation marker for …

PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many
organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this …

DNA damage tolerance plays a key role in protecting cell viability through translesion
synthesis and template switching-mediated bypass of genotoxic polymerase-blocking base …

ABSTRACT DNA damage repair is a crucial cellular mechanism for rectifying DNA lesions
arising during growth and development. Among the various repair pathways, postreplication …