Memory T cells: promising biomarkers for evaluating protection and vaccine efficacy against leishmaniasis
M Nateghi-Rostami, Y Sohrabi - Frontiers in Immunology, 2024 - frontiersin.org
Understanding the immune response to Leishmania infection and identifying biomarkers
that correlate with protection are crucial for developing effective vaccines. One intriguing …
that correlate with protection are crucial for developing effective vaccines. One intriguing …
The intersection of host in vivo metabolism and immune responses to infection with kinetoplastid and apicomplexan parasites
S Ewald, A Nasuhidehnavi, TY Feng… - Microbiology and …, 2024 - Am Soc Microbiol
Protozoan parasite infection dramatically alters host metabolism, driven by immunological
demand and parasite manipulation strategies. Immunometabolic checkpoints are often …
demand and parasite manipulation strategies. Immunometabolic checkpoints are often …
Understanding Resistance vs. Susceptibility in Visceral Leishmaniasis Using Mouse Models of Leishmania infantum Infection
B Pérez-Cabezas, P Cecílio, TB Gaspar… - Frontiers in cellular …, 2019 - frontiersin.org
Every year, up to 90,000 new cases of Visceral Leishmaniasis and 30,000 resultant deaths
are estimated to occur worldwide. Such numbers give relevance to the continuous study of …
are estimated to occur worldwide. Such numbers give relevance to the continuous study of …
Subcutaneous Immunization of Leishmania HSP70-II Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice
Leishmania infantum parasites cause a severe form of visceral leishmaniasis in human and
viscerocutaneous leishmaniasis in dogs. Recently, we reported that immunization with an …
viscerocutaneous leishmaniasis in dogs. Recently, we reported that immunization with an …
Cytokines in the immunity and immunopathogenesis in leishmaniases
B Saha, R Silvestre - Cytokine, 2021 - Elsevier
Cytokines are key mediators of immune responses to autoantigens, tumor antigens and
foreign antigens including pathogens and transplant antigens. The cytokines are produced …
foreign antigens including pathogens and transplant antigens. The cytokines are produced …
[HTML][HTML] The absence of HIF-1α increases susceptibility to Leishmania donovani infection via activation of BNIP3/mTOR/SREBP-1c axis
Summary Hypoxia-inducible factor-1 alpha (HIF-1α) is considered a global regulator of
cellular metabolism and innate immune cell functions. Intracellular pathogens such as …
cellular metabolism and innate immune cell functions. Intracellular pathogens such as …
Effects of Leishmania major infection on the gut microbiome of resistant and susceptible mice
Cutaneous leishmaniasis, a parasitic disease caused by Leishmania major, is a widely
frequent form in humans. To explore the importance of the host gut microbiota and to …
frequent form in humans. To explore the importance of the host gut microbiota and to …
The drug resistance mechanisms in Leishmania donovani are independent of immunosuppression
The protozoan parasite L. donovani resides inside macrophages as amastigotes and inflicts
a potentially lethal disease visceral leishmaniasis (VL). Due to absence of a vaccine …
a potentially lethal disease visceral leishmaniasis (VL). Due to absence of a vaccine …
Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3
Unveiling the protective immune response to visceral leishmaniasis is critical for a rational
design of vaccines aimed at reducing the impact caused by this fatal, if left untreated, vector …
design of vaccines aimed at reducing the impact caused by this fatal, if left untreated, vector …
Resistance to Experimental Visceral Leishmaniasis in Mice Infected With
Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Page 179 ORIGINAL
RESEARCH published: 10 December 2020 doi: 10.3389/fimmu. 2020.590934 Resistance to …
RESEARCH published: 10 December 2020 doi: 10.3389/fimmu. 2020.590934 Resistance to …