Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
The coagulopathy, endotheliopathy, and vasculitis of COVID-19
Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the
elevated D-dimer without remarkable changes of other global coagulation markers is …
elevated D-dimer without remarkable changes of other global coagulation markers is …
Microvascular dysfunction in COVID-19: the MYSTIC study
Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated
vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ …
vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ …
Endothelial dysfunction and immunothrombosis in sepsis
E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
Vasculopathy in COVID-19
R Flaumenhaft, K Enjyoji… - Blood, The Journal of the …, 2022 - ashpublications.org
COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …
involvement of the vasculature. Vascular involvement leads to an array of complications …
Bacterial endotoxin activates the coagulation cascade through gasdermin D-dependent phosphatidylserine exposure
X Yang, X Cheng, Y Tang, X Qiu, Y Wang, H Kang… - Immunity, 2019 - cell.com
Excessive activation of the coagulation system leads to life-threatening disseminated
intravascular coagulation (DIC). Here, we examined the mechanisms underlying the …
intravascular coagulation (DIC). Here, we examined the mechanisms underlying the …
[HTML][HTML] Thromboinflammation in acute injury: infections, heatstroke, and trauma
Tissue microcirculation is essential for the maintenance of organ homeostasis. Following
acute infections, activation of coagulation and inflammation, which are critical …
acute infections, activation of coagulation and inflammation, which are critical …
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy
Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …
[HTML][HTML] The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline
D Janosevic, J Myslinski, TW McCarthy, A Zollman… - Elife, 2021 - elifesciences.org
Sepsis is a dynamic state that progresses at variable rates and has life-threatening
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of …
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of …
The pulmonary pathology of COVID-19
H Bösmüller, M Matter, F Fend, A Tzankov - Virchows Archiv, 2021 - Springer
The lung is the main affected organ in severe coronavirus disease 2019 (COVID-19) caused
by the novel coronavirus SARS-CoV-2, and lung damage is the leading cause of death in …
by the novel coronavirus SARS-CoV-2, and lung damage is the leading cause of death in …