Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Total or near-total loss of insulin-producing β-cells occurs in type 1 diabetes,. Restoration of
insulin production in type 1 diabetes is thus a major medical challenge. We previously …

Pancreatic insulin-producing β-cells have a long lifespan, such that in healthy conditions
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …

Deciphering mechanisms of endocrine cell induction, specification and lineage allocation in
vivo will provide valuable insights into how the islets of Langerhans are generated …

All pancreatic endocrine cell types arise from a common endocrine precursor cell
population, yet the molecular mechanisms that establish and maintain the unique gene …

Cre/LoxP has broad utility for studying the function, development, and oncogenic
transformation of pancreatic cells in mice. Here we provide an overview of the Cre driver …

Classic experiments such as somatic cell nuclear transfer into oocytes and cell fusion
demonstrated that differentiated cells are not irreversibly committed to their fate. More recent …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

Genetic studies have implicated Notch signaling in the maintenance of pancreatic
progenitors. However, how Notch signaling regulates the quiescent, proliferative or …