Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Eukaryotic replication disrupts each nucleosome as the fork passes, followed by reassembly
of disrupted nucleosomes and incorporation of newly synthesized histones into …

Background The histone H3 variant CENP-A is normally tightly regulated to ensure only one
centromere exists per chromosome. Native CENP-A is often found overexpressed in human …

Histone variants fine-tune transcription, replication, DNA damage repair, and faithful
chromosome segregation. Whether and how nucleosome variants encode unique …

Centromeres are specialized domains of heterochromatin that provide the foundation for the
kinetochore. Centromeric heterochromatin is characterized by specific histone modifications …

The histone H3 variant CENP-A marks centromeres epigenetically and is essential for
mitotic fidelity. Previous crystallographic studies of the CENP-A nucleosome core particle …

Nucleosomes, the fundamental units of chromatin, regulate readout and expression of
eukaryotic genomes. Single-molecule experiments have revealed force-induced …

Centromeres are key chromosomal landmarks important for chromosome segregation and
are characterized by distinct chromatin features. The centromeric histone H3 variant …

Histone variants are an important part of the histone contribution to chromatin epigenetics. In
this review, we describe how the known structural differences of these variants from their …

All eukaryotic genomes are packaged into basic units of DNA wrapped around histone
proteins called nucleosomes. The ability of histones to specify a variety of epigenetic states …