Synaptic plasticity on motoneurons after axotomy: a necessary change in paradigm
FJ Alvarez, TM Rotterman, ET Akhter… - Frontiers in Molecular …, 2020 - frontiersin.org
Motoneurons axotomized by peripheral nerve injuries experience profound changes in their
synaptic inputs that are associated with a neuroinflammatory response that includes local …
synaptic inputs that are associated with a neuroinflammatory response that includes local …
Neural circuit mechanisms of sensorimotor disability in cancer treatment
SN Housley, P Nardelli… - Proceedings of the …, 2021 - National Acad Sciences
Cancer survivors rank sensorimotor disability among the most distressing, long-term
consequences of chemotherapy. Disorders in gait, balance, and skilled movements are …
consequences of chemotherapy. Disorders in gait, balance, and skilled movements are …
Adaptation of muscle activation after patellar loading demonstrates neural control of joint variables
We evaluated whether the central nervous system (CNS) chooses muscle activations not
only to achieve behavioral goals but also to minimize stresses and strains within joints. We …
only to achieve behavioral goals but also to minimize stresses and strains within joints. We …
The clinical significance of genetic variation in ovarian cancer
Genetic variation is a well-known contributor to the onset and progression of cancer. The
goal of this study is to provide a comprehensive examination of the nucleotide and …
goal of this study is to provide a comprehensive examination of the nucleotide and …
Axon initial segment geometry in relation to motoneuron excitability
The axon initial segment (AIS) responsible for action potential initiation is a dynamic
structure that varies and changes together with neuronal excitability. Like other neuron …
structure that varies and changes together with neuronal excitability. Like other neuron …
Structural preservation does not ensure function at sensory Ia–motoneuron synapses following peripheral nerve injury and repair
TM Rotterman, VV García, SN Housley… - Journal of …, 2023 - Soc Neuroscience
Injury that severs peripheral nerves often results in long-lasting motor behavioral deficits and
in reorganization of related spinal motor circuitry, neither of which reverse even after nerve …
in reorganization of related spinal motor circuitry, neither of which reverse even after nerve …
An assessment of co-contraction in reinnervated muscle
Aim: To investigate co-contraction in reinnervated elbow flexor muscles following a nerve
transfer. Materials & methods: 12 brachial plexus injury patients who received a nerve …
transfer. Materials & methods: 12 brachial plexus injury patients who received a nerve …
Mechanosensory encoding dysfunction emerges from cancer-chemotherapy interaction
Persistent sensory, motor and cognitive disabilities comprise chemotherapy-induced neural
disorders (CIND) that limit quality of life with little therapeutic relief for cancer survivors. Our …
disorders (CIND) that limit quality of life with little therapeutic relief for cancer survivors. Our …
Chronic defects in intraspinal mechanisms of spike encoding by spinal motoneurons following chemotherapy
Chemotherapy-induced sensorimotor disabilities, including gait and balance disorders, as
well as physical fatigue often persist for months and sometimes years into disease free …
well as physical fatigue often persist for months and sometimes years into disease free …
Excitatory and inhibitory descending commissural interneurons differentially integrate supraspinal and segmental sensory signals
A Giorgi, AT Cer, S Mohan… - Journal of …, 2023 - Soc Neuroscience
The limited information about how descending inputs from the brain and sensory inputs from
the periphery use spinal cord interneurons (INs) is a major barrier to understanding how …
the periphery use spinal cord interneurons (INs) is a major barrier to understanding how …