A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …

Background: Accumulating evidence has suggested that there is a positive association
between asthma and cardiovascular diseases (CVDs), implying a common architecture …

Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin
cells in the adrenal gland. However, the cellular molecular characteristics and immune …

Abstract N-methyltransferase (NMT)-catalyzed methylation at the termini of nonribosomal
peptides (NRPs) has rarely been reported. Here, we discover a fungal NMT LcsG for the …

Nicotinamide N‐methyltransferase (NNMT) methylates nicotinamide and has been
associated with various diseases. Herein, we report the first cell‐potent NNMT bisubstrate …

The purpose of this investigation was to compare the impacts of a potential blood flow
restriction (BFR)-betaine synergy on one-leg press performance, lactate concentrations, and …

Chiral pollutants often pose significant differential environmental health risks. In this study,
the biotransformation of chiral dinotefuran (DIN) and its enantioselective metabolic toxicity …

Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine
(SAM)-dependent methylation of norepinephrine to form epinephrine. Epinephrine is …

Bisubstrate strategies address the lack of specificity encountered with S‐adenosyl‐L‐
methionine (SAM) analogues targeting methyltransferases (MTases). Specifically, a …