The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Exosomes are implicated in cancer cell development, migration and invasion. Pigment
epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung …

Simple Summary While more efficient cancer treatments have led to a better quality of life
and to five-year survival rates of over 85% for localized tumors, these rates remain below …

Background The accumulation of M1-polarized macrophages and excessive inflammation
are important in the pathogenesis of diabetic foot ulcer (DFU). However, the underlying …

Nowadays it is perfectly clear that understanding and eradicating cancer cell invasion and
metastasis represent the crucial, definitive points in cancer therapeutics. During the last two …

Serine proteinase inhibitor B9 (serpin B9) is a member of the serine protease inhibitor
superfamily, which is widely found in animals, plants and microorganisms. Serpin B9 has …

Purpose: Estrogen-related receptor alpha (ERRα) signaling has recently been implicated in
breast cancer. We investigated the clinical value of ERRα in randomized cohorts of …

Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein that belongs to the
serine protease inhibitor (serpin) family. An increase in PEDF activity has been shown to be …