Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases
Background: The IL-17 (interleukin 17) family consists of six structurally related pro-
inflammatory cytokines, namely IL-17A to IL-17F. These cytokines have garnered significant …
inflammatory cytokines, namely IL-17A to IL-17F. These cytokines have garnered significant …
The key role of TNF-TNFR2 interactions in the modulation of allergic inflammation: a review
Tumor necrosis factor-alpha (TNF) is a pleiotropic cytokine, which is thought to play a major
role in the pathogenesis of inflammatory diseases, including allergy. TNF is produced at the …
role in the pathogenesis of inflammatory diseases, including allergy. TNF is produced at the …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis
Q Zhou, X Wu, X Wang, Z Yu, T Pan, Z Li, X Chang… - Oncogene, 2020 - nature.com
Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor
prognosis. In most cases, GC progression is associated with aberrant expression of …
prognosis. In most cases, GC progression is associated with aberrant expression of …
Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation
Y Su, J Huang, X Zhao, H Lu, W Wang, XO Yang… - Science …, 2019 - science.org
T helper 17 (TH17) cells and interleukin-17A (IL-17A) produced by them are critical in
autoinflammatory diseases, such as psoriasis. IL-17A has been shown to signal through IL …
autoinflammatory diseases, such as psoriasis. IL-17A has been shown to signal through IL …
TRAF regulation of IL-17 cytokine signaling
S Swaidani, C Liu, J Zhao, K Bulek, X Li - Frontiers in immunology, 2019 - frontiersin.org
Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important
mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue …
mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue …
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion
D Su, Y Cheng, S Li, D Dai, W Zhang, M Lv - Journal of Neuroimmunology, 2017 - Elsevier
Abstract Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating
sphingosine into sphingosine1-phosphate (S1P), plays an important role in mediating post …
sphingosine into sphingosine1-phosphate (S1P), plays an important role in mediating post …
Targeting of tumor necrosis factor alpha receptors as a therapeutic strategy for neurodegenerative disorders
Y Dong, DW Dekens, PP De Deyn, PJW Naudé… - Antibodies, 2015 - mdpi.com
Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha
(TNF-α), and have linked it with several neurodegenerative disorders. This review describes …
(TNF-α), and have linked it with several neurodegenerative disorders. This review describes …
The tumor necrosis factor family: family conventions and private idiosyncrasies
D Wallach - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
The tumor necrosis factor (TNF) cytokine family and the TNF/nerve growth factor (NGF)
family of their cognate receptors together control numerous immune functions, as well as …
family of their cognate receptors together control numerous immune functions, as well as …
Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling
S Pande, X Yang, R Friesel - Cell Communication and Signaling, 2021 - Springer
Abstract Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar
expression to fibroblast growth factor), is a single pass transmembrane protein that is …
expression to fibroblast growth factor), is a single pass transmembrane protein that is …