KIR and HLA under pressure: evidences of coevolution across worldwide populations
DG Augusto, ML Petzl-Erler - Human genetics, 2015 - Springer
KIR (killer cell immunoglobulin-like receptors) and HLA (human leukocyte antigens) are two
distinct gene families with remarkable importance for human immune responses. The …
distinct gene families with remarkable importance for human immune responses. The …
The Impact of KIR Polymorphism on the Risk of Developing Cancer: Not as Strong as Imagined?
DG Augusto - Frontiers in genetics, 2016 - frontiersin.org
The polymorphism of killer cell immunoglobulin-like receptors (KIR) has been associated
with several diseases, including infection, autoimmunity and cancer. KIR molecules are a …
with several diseases, including infection, autoimmunity and cancer. KIR molecules are a …
Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
NBR de Sá, M Ribeiro-Alves, TP da Silva… - BMC Infectious …, 2020 - Springer
Abstract Background Tuberculosis (TB) and AIDS are the leading causes of infectious
disease death worldwide. In some TB-HIV co-infected individuals treated for both diseases …
disease death worldwide. In some TB-HIV co-infected individuals treated for both diseases …
Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease
DG Augusto, SC Lobo-Alves, MF Melo, NF Pereira… - PloS one, 2012 - journals.plos.org
The KIR genes and their HLA class I ligands have thus far not been investigated in
pemphigus foliaceus (PF) and related autoimmune diseases, such as pemphigus vulgaris …
pemphigus foliaceus (PF) and related autoimmune diseases, such as pemphigus vulgaris …
Killer-Cell immunoglobulin-like receptor diversity in an admixed South American population
M Castrillon, ND Marin, AJ Karduss-Urueta… - Cells, 2022 - mdpi.com
Natural Killer (NK) cells are innate immune cells that mediate antiviral and antitumor
responses. NK cell activation and induction of effector functions are tightly regulated by the …
responses. NK cell activation and induction of effector functions are tightly regulated by the …
Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region
L de Brito Vargas, MH Beltrame, B Ho… - Molecular biology …, 2022 - academic.oup.com
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …
KIR Gene Content in Amerindians Indicates Influence of Demographic Factors
DG Augusto, BZ Piovezan, LT Tsuneto… - PLoS …, 2013 - journals.plos.org
Although the KIR gene content polymorphism has been studied worldwide, only a few
isolated or Amerindian populations have been analyzed. This extremely diverse gene family …
isolated or Amerindian populations have been analyzed. This extremely diverse gene family …
Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop
MK Misra, DG Augusto, GM Martin, N Nemat-Gorgani… - Human immunology, 2018 - Elsevier
The goals of the KIR component of the 17th International HLA and Immunogenetics
Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at …
Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at …
16th IHIW: Population Global Distribution of Killer Immunoglobulin‐like Receptor (KIR) and Ligands
In the last fifteen years, published reports have described KIR gene‐content frequency
distributions in more than 120 populations worldwide. However, there have been limited …
distributions in more than 120 populations worldwide. However, there have been limited …
Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA‐A3 and A11 in vivo
DG Augusto, GM O'Connor… - European journal of …, 2015 - Wiley Online Library
Although HLA‐A3 and A11 have been reported to be ligands for KIR3DL2, evidence for any
in vivo relevance of this interaction is still missing. To explore the functional importance of …
in vivo relevance of this interaction is still missing. To explore the functional importance of …