[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
Epigenome editing technologies for discovery and medicine
Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …
include elucidating gene regulation mechanisms, annotating coding and noncoding …
Deciphering the impact of genomic variation on function
Code of Conduct Committee (alphabetical by last name … - Nature, 2024 - nature.com
Our genomes influence nearly every aspect of human biology—from molecular and cellular
functions to phenotypes in health and disease. Studying the differences in DNA sequence …
functions to phenotypes in health and disease. Studying the differences in DNA sequence …
Scalable functional assays for the interpretation of human genetic variation
Scalable sequence–function studies have enabled the systematic analysis and cataloging of
hundreds of thousands of coding and noncoding genetic variants in the human genome …
hundreds of thousands of coding and noncoding genetic variants in the human genome …
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Comprehensive enhancer discovery is challenging because most enhancers, especially
those contributing to complex diseases, have weak effects on gene expression. Our gene …
those contributing to complex diseases, have weak effects on gene expression. Our gene …
The functional and evolutionary impacts of human-specific deletions in conserved elements
Conserved genomic sequences disrupted in humans may underlie uniquely human
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation
A scarcity of functionally validated enhancers in the human genome presents a significant
hurdle to understanding how these cis-regulatory elements contribute to human diseases …
hurdle to understanding how these cis-regulatory elements contribute to human diseases …
Breaking enhancers to gain insights into developmental defects
DA Armendariz, A Sundarrajan, GC Hon - Elife, 2023 - elifesciences.org
Despite ground-breaking genetic studies that have identified thousands of risk variants for
developmental diseases, how these variants lead to molecular and cellular phenotypes …
developmental diseases, how these variants lead to molecular and cellular phenotypes …
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
Genome-wide association studies (GWASs) have uncovered hundreds of autoimmune
disease-associated loci; however, the causal genetic variants within each locus are mostly …
disease-associated loci; however, the causal genetic variants within each locus are mostly …
Multicenter integrated analysis of noncoding CRISPRi screens
The ENCODE Consortium's efforts to annotate noncoding cis-regulatory elements (CREs)
have advanced our understanding of gene regulatory landscapes. Pooled, noncoding …
have advanced our understanding of gene regulatory landscapes. Pooled, noncoding …