Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of
childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by …

A major aim of HLA and disease association studies is to identify the causative HLA factor
truly responsible for the association. This is usually difficult due to the pronounced linkage …

Susceptibility to anti-glomerular basement membrane disease is strongly associated with
HLA-DRB1 genes. Anti-glomerular basement membrane (anti-GBM) disease is caused by …

Juvenile chronic arthritis UCA) is the term coined in 1977 by members of the European
League Against Rheumatism to describe a clinically heterogeneous group of idiopathic …

The information available on the specific function of HLA‐DP and the structure–function
relationships is very limited. Here, single amino acid substitutions of HLA‐DPB1* 02012 …

Juvenile idiopathic arthritis (JIA) is highly heterogeneous in terms of etiology and clinical
presentation with ambiguity in JIA classification. The advance of high-throughput omics …

Objective Anti–cyclic citrullinated peptide (anti‐CCP) antibodies have been detected in
patients with juvenile rheumatoid arthritis (JRA), particularly in those with polyarticular …

Endemic pemphigus foliaceus (EPF) is a blistering skin disease characterized by
autoantibodies against the desmosomal protein desmoglein 1. Genetic and environmental …

Chapter summary The chronic arthropathies of childhood share clinical and pathological
features with rheumatoid arthritis (RA) in adults. Both are autoimmune diseases …

The major histocompatibility complex class II alleles at the HLA-DPB1 locus were
investigated in 32 German Caucasoid patients with primary biliary cirrhosis (PBC) and …