The use of computer-aided drug design (CADD) for the identification of lead compounds in
radiotracer development is steadily increasing. Traditional CADD methods, such as structure …

Cannabidiol (CBD) and rivastigmine have been launched as drugs for treating dementia
and cholinesterases (ChEs) are ideal drug targets. This study focused on developing novel …

P-gp-associated multidrug resistance is a major impediment to the success of
chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we …

In medicinal chemistry, it is extremely important to evaluate, as accurately as possible, the
molecular interactions involved in the formation of different ligand-receptor (LR) complexes …

A series of 14 target benzyl [2-(arylsulfamoyl)-1-substituted-ethyl] carbamates was prepared
by multi-step synthesis and characterized. All the final compounds were tested for their …

Niemann–Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations
in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These mutations result in …

Background: Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to
form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an …

Sphingosine-1-phosphate is now emerging as an important player in cancer, inflammation,
autoimmune, neurological and cardiovascular disorders. Abundance evidence in animal …

We report here a new ligand for the peroxisome-proliferator-activated receptor type α
(PPARα), an N-tosyl hydrazone benzopyran that was designed throughout the mapping of …

Trypanosoma cruzi, a flagellate protozoan parasite, is responsible for Chagas disease. The
parasite major cysteine protease, cruzain (Cz), plays a vital role at every stage of its life cycle …