Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

Activation of cell-surface receptors by appropriate ligands causes the generation of second
messengers which are released in the cell interior. Such transmembrane signalling …

Thrombospondin (TSP) signals focal adhesion disassembly (the intermediate adhesive
state) through interactions with cell surface calreticulin (CRT). TSP or a peptide (hep I) of the …

I. Introduction T HE ROLE of heterotrimeric guanine nucleotide binding proteins (G proteins)
in signal transduction was first covered in Endocrine Reviews in 1981, when three distinct G …

The precise mechanism whereby epidermal growth factor (EGF) activates the serine-
threonine kinase Akt and the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) …

During development of the nervous system, cell adhesion molecules (CAMS) promote cell
migration and axonal growth; yet, at other times, CAMS inhibit these events by maintaining …

During gamete interaction, sperm acrosome reaction (AR) induced by oocyte investment is a
prerequisite event for the spermatozoa to pass through the zona pellucida (ZP), fuse with …

Cerebellar neurons, cultured on monolayers of 3T3 fibroblasts or on a polylysine/laminin-
coated substratum, responded to recombinant basic FGF by extending longer neurites. The …

We have used monolayers of control 3T3 fibroblasts and 3T3 fibroblasts expressing
transfected cell adhesion molecules (CAMs)—NCAM, N‐cadherin, and L1—as a culture …

Fertilization is initiated by the species-specific binding of sperm to the extracellular coat of
the egg. One sperm receptor for the mouse egg is β-1, 4-galactosyltransferase (GalTase) …