Hypophysitis is defined as inflammation of the pituitary gland that is primary or secondary to
a local or systemic process. Differential diagnosis is broad (including primary tumors …

Immune checkpoint inhibitors (ICIs) belong to a new group of anticancer drugs targeting T-
cell proteins involved in the activation of immune response toward malignancies. Their …

Hypophysitis is a heterogeneous condition that leads to inflammation of the sella and/or
suprasellar region, potentially resulting in hormonal deficiencies and/or mass effects. A …

Hypopituitarism is defined as a complete or partial deficiency in one or more pituitary
hormones. Anterior hypopituitarism includes secondary adrenal insufficiency, central …

A variety of inflammatory conditions may directly involve the endocrine glands, leading to
endocrine dysfunction that can cause severe consequences on patients' health, if left …

Immune control point (ICI) inhibitors represent a significant advance in the management and
survival of cancers such as melanoma or non-small cell bronchial carcinoma. However, they …

Introduction: Lymphocytic hypophysitis (LH) is a rare autoimmune disorder involving the
destruction of the anterior pituitary due to lymphocytic infiltration. The disease shows a …

Pituitary autoimmunity is one of the principal causes of hypopituitarism. Additionally,
hypophysitis is one of the immune-related adverse events associated with immunotherapy …

Hypopituitarism is caused by various insults to the pituitary, such as hypothalamic and
pituitary tumors, inflammation, autoimmunity, vascular injury, genetic abnormalities …

Abstract BACKGROUND The World Health Organization (WHO) system for the classification
of disorders of ovulation was produced 50 years ago and, by international consensus, has …