Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

Population balance models are tools for the study of dispersed systems, such as granular
materials, polymers, colloids and aerosols. They are applied with increasing frequency …

In this research, degradation of three sulfonamide antibiotic compounds (SNAs) such as
Sulfasalazine (SSZ), Sulfamethoxazole (SMX) and Sulfamethazine (SMT) as well as …

In this study, machine learning (ML) computations were carried out for description of drug
solubility in supercritical carbon dioxide. Supercritical solvent has been used in this work …

In this study, a complete two dimensional (internal coordinates) population balance model
(2D-PBM) is developed, calibrated and validated as a predictive tool for predicting the …

In recent years, continuous twin-screw wet granulation (TSWG) is gaining increasing interest
from the pharmaceutical industry. Despite the many publications on TSWG, only a limited …

In this study, a compartmental population balance model (CPBM) is developed as a
predictive tool of particle size distribution (PSD) for wet granulation in co-rotating twin-screw …

A hybrid model was developed for simulation of continuous wet granulation of
pharmaceutical formulations via twin-screw granulator. The model was based on population …

This paper presents a generic framework of Model Driven Design (MDD) with its application
for a twin screw granulation process using a mechanistic-based population balance model …

Continuous twin screw wet granulation is one of the key continuous manufacturing
technologies that have gained significant interest in the pharmaceutical industry as well as …