Aflatoxin B1: Metabolism, toxicology, and its involvement in oxidative stress and cancer development

W Cao, P Yu, KP Yang, D Cao - Toxicology Mechanisms and …, 2022 - Taylor & Francis
Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi, which are
widely distributed in nature. Aflatoxin B1 (AFB1) is the most toxic of these compounds and its …

Therapeutic detoxification of quercetin for aflatoxin B1-related toxicity: Roles of oxidative stress, inflammation, and metabolic enzymes

C Dai, G Sharma, G Liu, J Shen, B Shao, Z Hao - Environmental Pollution, 2024 - Elsevier
Aflatoxins (AFTs), a type of mycotoxin mainly produced by Aspergillus parasiticus and
Aspergillus flavus, could be detected in food, feed, Chinese herbal medicine, grain crops …

Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney …

SE Owumi, AI Kazeem, B Wu, LO Ishokare… - Scientific reports, 2022 - nature.com
Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …

Contamination of aflatoxins induces severe hepatotoxicity through multiple mechanisms

Z Hua, R Liu, Y Chen, G Liu, C Li, Y Song… - Frontiers in …, 2021 - frontiersin.org
Aflatoxins (AFs) are commonly contaminating mycotoxins in foods and medicinal materials.
Since they were first discovered to cause “turkey X” disease in the United Kingdom in the …

Resveratrol Relieved Acute Liver Damage in Ducks (Anas platyrhynchos) Induced by AFB1 via Modulation of Apoptosis and Nrf2 Signaling Pathways

F Liu, Y Wang, X Zhou, M Liu, S Jin, A Shan, X Feng - Animals, 2021 - mdpi.com
Simple Summary Aflatoxin B1 is ubiquitous in food and feed, which not only poses a great
threat to animals, but also affects human health. It is unclear whether resveratrol can resist …

Nrf2: A main responsive element in cells to mycotoxin-induced toxicity

MJ Kozieł, K Kowalska… - Archives of Toxicology, 2021 - Springer
Abstract Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor participating in
response to cellular oxidative stress to maintain the redox balance. Generation of reactive …

Dietary curcumin alleviated aflatoxin b1-induced acute liver damage in ducks by regulating nlrp3–caspase-1 signaling pathways

S Jin, H Yang, Y Wang, Q Pang, Y Jiao, A Shan… - Foods, 2021 - mdpi.com
Aflatoxin B1 (AFB1) is a mycotoxin widely distributed in animal feed and human food; it
represents a serious threat to human and animal health. This study investigates the …

Hepatotoxicity of food-borne mycotoxins: Molecular mechanism, anti-hepatotoxic medicines and target prediction

H Ruan, Q Lu, J Wu, J Qin, M Sui, X Sun… - Critical Reviews in …, 2022 - Taylor & Francis
Mycotoxins are metabolites produced by fungi. The widespread contamination of food and
feed by mycotoxins is a global food safety problem and a serious threat to people's health …

[HTML][HTML] Bacillus amyloliquefaciens B10 can alleviate aflatoxin B1-induced kidney oxidative stress and apoptosis in mice

Y Zhao, T Wang, P Li, J Chen, E Nepovimova… - Ecotoxicology and …, 2021 - Elsevier
Abstract Aflatoxin B1 (AFB1) widely exists in food and feed, which seriously endangers
human and animal health. How to detoxify AFB1 is a research hotspot at present. This study …

Targeting SIRT1/AMPK/Nrf2/NF-кB by sitagliptin protects against oxidative stress-mediated ER stress and inflammation during ANIT-induced cholestatic liver injury

RM Mosaoa, MW Al-Rabia, HZ Asfour, NA Alhakamy… - Toxicology, 2024 - Elsevier
Highlights•SIRT1/AMPK signaling regulates oxidative stress-mediated ER stress and
inflammation•Sitagliptin activates SIRT1/AMPK regulatory axis during cholestatic liver …