Drugs involved in dyslipidemia and obesity treatment: focus on adipose tissue

S Dias, S Paredes, L Ribeiro - International journal of …, 2018 - Wiley Online Library
Metabolic syndrome can be defined as a state of disturbed metabolic homeostasis
characterized by visceral obesity, atherogenic dyslipidemia, arterial hypertension, and …

Apolipoprotein A‐I: Insights from redox proteomics for its role in neurodegeneration

JTR Keeney, AM Swomley, S Förster… - PROTEOMICS …, 2013 - Wiley Online Library
Proteomics has a wide range of applications, including determination of differences in the
proteome in terms of expression and post‐translational protein modifications. Redox …

Potential predictive plasma biomarkers for cervical cancer by 2D-DIGE proteomics and Ingenuity Pathway Analysis

X Guo, Y Hao, M Kamilijiang, A Hasimu, J Yuan, G Wu… - Tumor Biology, 2015 - Springer
The current methods available for screening and detecting cervical squamous cell
carcinoma (CSCC) have insufficient sensitivity and specificity. As a result, many patients …

[HTML][HTML] Psoriasis skin inflammation-induced microRNA-26b targets NCEH1 in underlying subcutaneous adipose tissue

L Cheung, RM Fisher, N Kuzmina, D Li, X Li… - Journal of Investigative …, 2016 - Elsevier
Psoriasis is an immune-mediated inflammatory disease, which is associated with a high risk
of developing systemic comorbidities, such as obesity, cardiovascular disease, and diabetes …

Effect of repeated apoA-IMilano/POPC infusion on lipids,(apo) lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys

HJ Kempen, M Gomaraschi, SE Bellibas… - Journal of lipid …, 2013 - ASBMB
MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-
phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 …

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

M Lindahl, J Petrlova, J Dalla-Riva, S Wasserstrom… - Journal of lipid …, 2015 - ASBMB
ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic
homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about …

Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice

KA Edgel, TS McMillen, H Wei, N Pamir… - … et Biophysica Acta (BBA …, 2012 - Elsevier
The prevalence of obesity has reached epidemic proportions and is associated with several
co-morbid conditions including diabetes, dyslipidemia, cancer, atherosclerosis and …

An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia

J Fan, S Stukas, C Wong, J Chan, S May… - Journal of Lipid …, 2011 - ASBMB
Lipid transport in the brain is coordinated by glial-derived lipoproteins that contain
apolipoprotein E (apoE) as their primary protein. Here we show that apoE is secreted from …

A computational model for the analysis of lipoprotein distributions in the mouse: translating FPLC profiles to lipoprotein metabolism

FLP Sips, CA Tiemann, MH Oosterveer… - PLoS computational …, 2014 - journals.plos.org
Disturbances of lipoprotein metabolism are recognized as indicators of cardiometabolic
disease risk. Lipoprotein size and composition, measured in a lipoprotein profile, are …

Signaling pathways of apoE and its role of gene expression in glomerulus diseases

TB Zhou - Journal of Receptors and Signal Transduction, 2013 - Taylor & Francis
The roles of apolipoprotein E (apoE) in regulating plasma lipids and lipoproteins levels have
been investigated for over several decades. However, in different tissues/cells, the role of …