Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
HA Elsebaie, EA El-Bastawissy, KM Elberembally… - Bioorganic …, 2023 - Elsevier
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Nicotinonitrile as an essential scaffold in medicinal chemistry: an updated review (2015–present)
Many studies have been carried out to find synthetic pathways to nicotinonitriles (3-
cyanopyridines) and their analogs, which has resulted in a substantial amount of knowledge …
cyanopyridines) and their analogs, which has resulted in a substantial amount of knowledge …
Synthesis and antimicrobial activity of pyrimidinyl 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles and 1, 2, 4-triazoles
MM Sekhar, U Nagarjuna, V Padmavathi… - European journal of …, 2018 - Elsevier
A new class of methylthio linked pyrimidinyl 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles and 1, 2,
4-triazoles were prepared under conventional and ultrasound irradiation methods. All the …
4-triazoles were prepared under conventional and ultrasound irradiation methods. All the …
Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole
D Seenaiah, PR Reddy, GM Reddy, A Padmaja… - European Journal of …, 2014 - Elsevier
A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio,
methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic …
methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic …
A Review: synthesis and medicinal importance of nicotinonitriles and their analogous
The biological, therapeutic, and medicinal properties of nicotinonitriles (cyanopyridines) and
its analogues have prompted enormous research aimed at developing synthetic routes to …
its analogues have prompted enormous research aimed at developing synthetic routes to …
Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties
As dual EGFR and BRAFV600E inhibitors, 2‐(3‐cyano‐4, 6‐bis (aryl)‐2‐oxo‐1, 2‐
dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed …
dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed …
Identification of 3‐(5‐cyano‐6‐oxo‐pyridin‐2‐yl) benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity
MA Shaldam, AF Khalil, H Almahli… - Archiv der …, 2024 - Wiley Online Library
Abstract New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides (6a–m and 8a–d) were
designed and synthesized to potentially inhibit both the epidermal growth factor receptor …
designed and synthesized to potentially inhibit both the epidermal growth factor receptor …
The cremeomycin biosynthetic gene cluster encodes a pathway for diazo formation
Diazo groups are found in a range of natural products that possess potent biological
activities. Despite longstanding interest in these metabolites, diazo group biosynthesis is not …
activities. Despite longstanding interest in these metabolites, diazo group biosynthesis is not …
Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kα/EGFR inhibitors
Abstract Structure-based drug design and molecular modeling were employed to identify a
new series of indole-2-carboxamides as potential anticancer agents. These compounds …
new series of indole-2-carboxamides as potential anticancer agents. These compounds …
In vivo efficacy studies of novel quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors, in lung cancer xenografts (NCI-H1975) mice models
D Das, L Xie, J Wang, J Shi, J Hong - Bioorganic Chemistry, 2020 - Elsevier
Lung cancer is the most common cancer and leading cause of cancer-related deaths
worldwide. The first-generation reversible, ATP-competitive inhibitors gefetinib and elotinib …
worldwide. The first-generation reversible, ATP-competitive inhibitors gefetinib and elotinib …