Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to
promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

Igniting thermogenesis within white adipose tissue (ie, promoting expression and activity of
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …

The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune
cells and cellular energy metabolism. Although glycolysis has been linked to immune …

Certain white adipose tissue (WAT) depots are readily able to convert to a “brown-like” state
with prolonged cold exposure or exposure to β-adrenergic compounds. This process is …

Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the
interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

We present a consolidated view of the complexity and challenges of designing studies for
measurement of energy metabolism in mouse models, including a practical guide to the …