β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

LI Hudish, JEB Reusch, L Sussel - The Journal of clinical …, 2019 - Am Soc Clin Investig
In a society where physical activity is limited and food supply is abundant, metabolic
diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster …

Is arsenic exposure a risk factor for metabolic syndrome? a review of the potential mechanisms

P Pánico, M Velasco, AM Salazar, A Picones… - Frontiers in …, 2022 - frontiersin.org
Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is
associated with increased risk of developing chronic diseases, including metabolic …

NGF and its role in immunoendocrine communication during metabolic syndrome

J Samario-Román, C Larqué, P Pánico… - International journal of …, 2023 - mdpi.com
Nerve growth factor (NGF) was the first neurotrophin described. This neurotrophin
contributes to organogenesis by promoting sensory innervation and angiogenesis in the …

Liraglutide compromises pancreatic β cell function in a humanized mouse model

MH Abdulreda, R Rodriguez-Diaz, A Caicedo… - Cell metabolism, 2016 - cell.com
Incretin mimetics are frequently used in the treatment of type 2 diabetes because they
potentiate β cell response to glucose. Clinical evidence showing short-term benefits of such …

The metabolic syndrome, a human disease

M Alemany - International journal of molecular sciences, 2024 - mdpi.com
This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

D Rebolledo-Solleiro, G Roldán-Roldán, D Diaz… - PLoS …, 2017 - journals.plos.org
Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes
mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the …

Molecular insulin actions are sexually dimorphic in lipid metabolism

RI Ortiz-Huidobro, M Velasco, C Larqué… - Frontiers in …, 2021 - frontiersin.org
The increment in energy-dense food and low physical activity has contributed to the current
obesity pandemic, which is more prevalent in women than in men. Insulin is an anabolic …

Sexual dimorphism in insulin resistance in a metabolic syndrome rat model

M Velasco, RI Ortiz-Huidobro, C Larqué… - Endocrine …, 2020 - ec.bioscientifica.com
Objective: We assessed the sex-specific differences in the molecular mechanisms of insulin
resistance in muscle and adipose tissue, in a MS rat model induced by a high sucrose diet …

Dietary energy partition: The central role of glucose

X Remesar, M Alemany - International journal of molecular sciences, 2020 - mdpi.com
Humans have developed effective survival mechanisms under conditions of nutrient (and
energy) scarcity. Nevertheless, today, most humans face a quite different situation: excess of …

Metabolic syndrome and ionic channels in pancreatic beta cells

M Hiriart, M Velasco, C Larqué, CM Diaz-Garcia - Vitamins & Hormones, 2014 - Elsevier
Worldwide increase in the prevalence of metabolic syndrome and diabetes mellitus type 2
(DM2) during the past decades has converted them into a global epidemic disease. It is not …