Homocysteine and age-associated disorders

EA Ostrakhovitch, S Tabibzadeh - Ageing research reviews, 2019 - Elsevier
There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

[HTML][HTML] Role of nutrition in the development and prevention of age-related hearing loss: A scoping review

L Rodrigo, C Campos-Asensio, MÁ Rodríguez… - Journal of the Formosan …, 2021 - Elsevier
Age-related hearing loss (ARHL) is a major and increasingly prevalent health problem
worldwide, causing disability and social isolation in the people who present it. This …

[HTML][HTML] Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

R Martínez-Vega, F Garrido, T Partearroyo… - The FASEB …, 2014 - pmc.ncbi.nlm.nih.gov
Nutritional imbalance is emerging as a causative factor of hearing loss. Epidemiologic
studies have linked hearing loss to elevated plasma total homocysteine (tHcy) and folate …

Interplay between nutrition and hearing loss: state of art

AM Puga, MA Pajares, G Varela-Moreiras… - Nutrients, 2018 - mdpi.com
Hearing loss has been recently ranked as the fifth leading cause of years lived with
disability, ahead of many other chronic diseases such as diabetes, dementia, or chronic …

[HTML][HTML] Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss …

R Martinez-Vega, T Partearroyo, N Vallecillo… - The Journal of …, 2015 - Elsevier
Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients well known for their
beneficial effects, among others on cognitive development and maintenance, inflammation …

Cochlear homocysteine metabolism at the crossroad of nutrition and sensorineural hearing loss

T Partearroyo, N Vallecillo, MA Pajares… - Frontiers in Molecular …, 2017 - frontiersin.org
Hearing loss (HL) is one of the most common causes of disability, affecting 360 million
people according to the World Health Organization (WHO). HL is most frequently of …

The effect of vitamin B12 on idiopathic tinnitus

M Dadgarnia, M Mandegari, V Zand… - American Journal of …, 2024 - Elsevier
Introduction Tinnitus is one of the most important challenges in the field of ear, nose and
throat diseases. The aim of this study was to evaluate the effect of vitamin B12 on idiopathic …

Hearing function and nutritional status in aviation pilots from Spain exposed to high acoustic damage

C Morais-Moreno, AM Montero-Bravo, AM Puga… - Nutrients, 2022 - mdpi.com
Noise-induced hearing loss is the most frequent and preventable occupational disease.
Aviation pilots are a vulnerable population, as they spend many hours exposed to noise …

[HTML][HTML] Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma …

T Partearroyo, S Murillo-Cuesta, N Vallecillo… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Betaine-homocysteine S-methyltransferases (BHMTs) are methionine cycle enzymes that
remethylate homocysteine; hence, their malfunction leads to hyperhomocysteinemia …

Long-term dietary folate deficiency accelerates progressive hearing loss on CBA/Ca mice

R Martínez-Vega, S Murillo-Cuesta… - Frontiers in Aging …, 2016 - frontiersin.org
Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months,
corroborates the epidemiological association previously described between vitamin …