Autoimmune diseases are a range of diseases in which the immune response to self-
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …

Women have a higher incidence and prevalence of autoimmune diseases than men, and
85% or more patients of multiple autoimmune diseases are female. Women undergo …

Background Treatment of patients younger than 18 years of age with multiple sclerosis has
not been adequately examined in randomized trials. We compared fingolimod with …

Background Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are
increasing globally. No disease-modifying therapy are approved for MS pediatric population …

Background The course and prognosis of childhood-onset multiple sclerosis have not been
well described. Methods We used data from 13 adult neurology departments affiliated with …

Forty-eight children with disseminated demyelination of the CNS, 28 with acute
disseminated encephalomyelitis (ADEM), seven with multiphasic disseminated …

Objective: To evaluate the clinical course of MS in individuals with onset of MS before age
16. Methods: Patients with onset of MS before age 16 (n= 116) with complete clinical …

Summary Background HLA-DRB1* 15 genotype, previous infection with Epstein-Barr virus,
and vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they …

Background: The incidence of acquired demyelination of the CNS (acquired demyelinating
syndromes [ADS]) in children is unknown. It is important that physicians recognize the …

The onset of multiple sclerosis (MS) in childhood poses diagnostic and therapeutic
challenges, particularly if the symptoms of the first demyelinating event resemble acute …