Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the
basis of the presence of mutations in protein-coding regions. By contrast, much less is …

Pioneer transcription factors have the unique and important role of unmasking chromatin
domains during development to allow the implementation of new cellular programs …

Forkhead-box (FOX) family proteins, involved in cell growth and differentiation as well as
embryogenesis and longevity, are DNA-binding proteins regulating transcription and DNA …

Breast tumors of the basal-like, hormone receptor–negative subtype remain an unmet
clinical challenge, as there is high rate of recurrence and poor survival in patients following …

The heterogeneous breast cancers can be classified into different subtypes according to
their histopathological characteristics and molecular signatures. Foxa1 expression is linked …

Eukaryotic DNA is packaged into chromatin in the nucleus, restricting the binding of
transcription factors (TFs) to their target DNA sites. FOXA1 functions as a pioneer TF to bind …

When aberrant, factors critical for organ morphogenesis are also commonly involved in
disease progression. FOXA1 (forkhead box A1), also known as HNF3α (hepatocyte nuclear …

FOXA1 and FOXA2, members of the forkhead transcription factor family, are critical for
epithelial differentiation in many endoderm-derived organs, including the pancreas …