Review of safety and efficacy of sleep medicines in older adults

JL Schroeck, J Ford, EL Conway, KE Kurtzhalts… - Clinical …, 2016 - Elsevier
Purpose Insomnia is problematic for older adults. After behavioral modifications fail to show
adequate response, pharmacologic options are used. The pharmacokinetics of agents used …

The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the non‐motor symptoms of Parkinson's disease

K Seppi, D Weintraub, M Coelho… - Movement …, 2011 - Wiley Online Library
Abstract The Movement Disorder Society (MDS) Task Force on Evidence‐Based Medicine
(EBM) Review of Treatments for Parkinson's Disease (PD) was first published in 2002 and …

Cognitive behavioral insomnia therapy for those with insomnia and depression: a randomized controlled clinical trial

CE Carney, JD Edinger, M Kuchibhatla, AM Lachowski… - Sleep, 2017 - academic.oup.com
Abstract Study Objective: To compare cognitive behavioral therapy for insomnia (CBT-I)+
antidepressant medication (AD) against treatments that target solely depression or solely …

Pyrazine and phenazine heterocycles: platforms for total synthesis and drug discovery

RW Huigens III, BR Brummel, S Tenneti, AT Garrison… - Molecules, 2022 - mdpi.com
There are numerous pyrazine and phenazine compounds that demonstrate biological
activities relevant to the treatment of disease. In this review, we discuss pyrazine and …

Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

GQ Chen, HY Guo, ZS Quan, QK Shen, X Li, T Luan - Molecules, 2023 - mdpi.com
Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Deliberate-characterization for Ni (II)-Schiff base complexes: promising in-vitro anticancer feature that matched MOE docking-approach

HM Abumelha, JH Al-Fahemi, I Althagafi… - Journal of Inorganic and …, 2020 - Springer
A novel series of Ni (II)-Schiff base complexes were synthesized from five hydrazide
derivatives. All new synthesizes were fully characterized applying analytical and spectral …

Facile synthesis of iodopyridines from N-propargylic β-enaminones via iodine-mediated electrophilic cyclization

S Karabiyikoglu, Y Kelgokmen, M Zora - Tetrahedron, 2015 - Elsevier
A facile, efficient and general synthetic method for iodopyridines is described. When treated
with molecular iodine in the presence of sodium bicarbonate, N-propargylic β-enaminones …

Non–benzodiazepine receptor agonists for insomnia

PM Becker, M Somiah - Sleep Medicine Clinics, 2015 - sleep.theclinics.com
Non–Benzodiazepine Receptor Agonists for Insomnia - Sleep Medicine Clinics Skip to Main
Content Skip to Main Menu Sleep Medicine Clinics Log in Register Log in Subscribe Claim …

Eszopiclone for the treatment of primary insomnia: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials

L Liang, Y Huang, R Xu, Y Wei, L Xiao, G Wang - Sleep Medicine, 2019 - Elsevier
Study objective In this study, we performed a systematic review and meta-analysis of double-
blind, randomized, placebo-controlled trials to evaluate the efficacy and safety of …

Facile synthesis of aryl-substituted pyridines via Suzuki–Miyaura approach

E Karadeniz, M Zora, NZ Kılıçaslan - Tetrahedron, 2015 - Elsevier
A facile and efficient synthetic route to arylpyridines is reported. When heated with boronic
acids in the presence of 5 mol% PdCl 2 (PPh 3) 2 and KHCO 3 in 4: 1 DMF/H 2 O solution at …