Significance of chalcone scaffolds in medicinal chemistry

R Mazumder, Ichudaule, A Ghosh, S Deb… - Topics in Current …, 2024 - Springer
Chalcone is a simple naturally occurring α, β-unsaturated ketone with biological importance,
which can also be easily synthesized in laboratories by reaction between two aromatic …

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

CMC Andrés, JM Pérez de la Lastra… - International Journal of …, 2024 - mdpi.com
The phrase “Let food be thy medicine…” means that food can be a form of medicine and
medicine can be a form of food; in other words, that the diet we eat can have a significant …

Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model

SPRR Nayak, LS Dhivya, R Reshma… - European Journal of …, 2023 - Elsevier
Abstract Inflammatory Bowel Disease (IBD) is a group of persistent intestinal illnesses
resulting from bowel inflammation unrelated to infection. The prevalence of IBD is rising in …

Structural and theoretical exploration of a multi-methoxy chalcone: Synthesis, quantum theory, electrostatics, molecular packing, DFT analysis, and in-silico anti …

FH Al-Ostoot, P Akhileshwari, VH Kameshwar… - Heliyon, 2024 - cell.com
This study explores the pharmacological potential of chalcones through a multidisciplinary
approach, including synthesis, quantum theory, molecular electrostatics, and density …

Synthesis and In vitro evaluation of bichalcones as novel anti-toxoplasma agents

F Mazzone, MKT Klischan, J Greb, SHJ Smits… - Frontiers in …, 2024 - frontiersin.org
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an apicomplexan
parasite that infects approximately a third of the world's human population. This disease can …

Development of a microbial-assisted process for enhanced astaxanthin recovery from crab exoskeleton waste

MN Abd El-Ghany, SA Hamdi, RM Elbaz, AS Aloufi… - Fermentation, 2023 - mdpi.com
Astaxanthin is a xanthophyll carotenoid possessing impressive nutraceutical, antioxidant,
and bioactive merits. Traditionally, astaxanthin is extracted from crustacean wastes via …

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles

S Hba, S Ghaddar, H Wahnou, A Pinon, R El Kebbaj… - Pharmaceutics, 2023 - mdpi.com
Colon cancer poses a complex and substantial global health challenge, necessitating
innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse …

Optimization and antifungal activity of quinoline derivatives linked to chalcone moiety combined with FLC against Candida albicans

A Sun, N Chai, X Zhu, Y Li, R Wang, Y Zhang… - European Journal of …, 2023 - Elsevier
In present work, a series of quinoline derivatives linked to chalcone moiety have been
prepared, and their in vitro and in vivo antifungal activities against C. albicans have been …

Elucidating bis-pyrimidines as new and efficient mushroom tyrosinase inhibitors: synthesis, SAR, kinetics and computational studies

M Afzal, R Mehmood, EU Mughal, N Naeem, Z Ashraf… - RSC …, 2024 - pubs.rsc.org
In this study, a series of novel bis-pyrimidine derivatives (1P–8P) were designed,
synthesized, characterized, and investigated for their in vitro inhibitory activity against …

Synthesis, Characterization, Antioxidant, and Anticancer Activity against Colon Cancer Cells of Some Cinnamaldehyde-Based Chalcone Derivatives

MA El-Atawy, DH Hanna, AH Bashal, HA Ahmed… - Biomolecules, 2024 - mdpi.com
The purpose of the current investigation was to produce cinammaldehyde-based chalcone
derivatives (3a–k) to evaluate their potential effectiveness as antioxidant and inhibitory …