Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

The regeneration of complex structures in adult salamanders depends on mechanisms that
offer pointers for regenerative medicine. These include the plasticity of differentiated cells …

Salamanders regenerate appendages via a progenitor pool called the blastema. The
cellular mechanisms underlying regeneration of muscle have been much debated but have …

With the explosion of knowledge from molecular biology and the burgeoning interest in
generating or regenerating tissues or organs through various bioengineering or stem cell …

This review explores the historical and current state of our knowledge about urodele limb
regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of …

An outstanding biological question is why tissue regeneration in mammals is limited,
whereas urodele amphibians and teleost fish regenerate major structures, largely by cell …

Cartilage is the first skeletal tissue to be formed during embryogenesis leading to the
creation of all mature cartilages and bones, with the exception of the flat bones in the skull …

Stem Cells and Drug Discovery: The Beginning of a New Era?: Cell Skip to Main Content
Advertisement Cell This journal offers authors two options (open access or subscription) to …

The experimental study of amphibian limb regeneration spans most of the 20th century and
the first decade of the 21st century. We first review the major questions investigated over this …

Dedifferentiation is an important biological phenomenon whereby cells regress from a
specialized function to a simpler state reminiscent of stem cells. Stem cells are self-renewing …