Owing to their outstanding performances in molecular recognition, antibodies are
extensively used in research and applications in molecular biology, biotechnology and …

As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain
overcome antibody size and complexity while maintaining analogous binding loops …

Identification of favorable biophysical properties for protein therapeutics as part of
developability assessment is a crucial part of the preclinical development process …

Protein aggregation is a phenomenon that has attracted considerable attention within the
pharmaceutical industry from both a developability standpoint (to ensure stability of protein …

Although antibodies have become the fastest-growing class of therapeutics on the market, it
is still challenging to develop them for therapeutic applications, which often require these …

Aggregation can be thought of as a form of protein folding in which intermolecular
associations lead to the formation of large, insoluble assemblies. Various types of …

Intracellular synthesis, folding, trafficking and degradation of proteins are controlled and
integrated by proteostasis. The frequency of protein misfolding disorders in the human …

In recent years, computational methods have garnered much attention in protein
engineering. A large number of computational methods have been developed to analyze the …

There has been a remarkable increase in the number of biologics, especially monoclonal
antibodies, in the market over the last decade. In addition to attaining the desired binding to …

Improved understanding of properties that mediate protein solubility and resistance to
aggregation are important for developing biopharmaceuticals, and more generally in …