It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Abstract Phosphoglycerate kinase 1 (PGK1) is an essential enzyme in the aerobic glycolysis
pathway. PGK1 catalyzes the reversible transfer of a phosphate group from 1, 3 …

Large scale genome sequencing allowed the identification of a massive number of genetic
variations, whose impact on human health is still unknown. In this review we analyze, by an …

Proton export is often considered a detoxifying process in animal cells, with
monocarboxylate symporters coexporting excessive lactate and protons during glycolysis or …

A central characteristic of many types of cancer is altered energy metabolism processes
such as enhanced glucose uptake and glycolysis and decreased oxidative metabolism. The …

Cells that undergo normal differentiation mainly rely on mitochondrial oxidative
phosphorylation to provide energy, but most tumour cells rely on aerobic glycolysis. This …

Understanding the molecular interaction between ligand and receptor is important for
providing the basis for the development of regenerative drugs. Although it has been reported …

Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …

Abstract Phosphoglycerate kinase 1 (PGK1) is an essential enzyme that catalyzes
adenosine 5′-triphosphate (ATP) production in aerobic glycolysis. In addition to regulating …

Phosphoglycerate kinase has been a model for the stability, folding cooperativity and
catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer …