Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

Antiviral transcriptional responses and regulated cell death are crucial components of the
host response to virus infection. However, in contrast to the signaling pathways that promote …

Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns
that mediate well established cytokine-driven pathways, activating NF-κB together with …

Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …

Recognition of pathogen-derived nucleic acids by pattern-recognition receptors (PRRs) is
essential for eliciting antiviral immune responses by inducing the production of type I …

Innate immunity represents the first line of defence against invading pathogens. It consists of
an initial inflammatory response that recruits white blood cells to the site of infection in an …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …

Ubiquitination is a post‐translational modification process that has been implicated in the
regulation of innate and adaptive immune responses. There is increasing evidence that both …

Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an
important role in physiology and disease, but the death-inducing signaling mechanisms are …

cFLIP (cellular FLICE-like inhibitory protein) is structurally related to caspase-8 but lacks
proteolytic activity due to multiple amino acid substitutions of catalytically important residues …