Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level
A Joachim, R Aussel, L Gélard, F Zhang… - Journal of Experimental …, 2023 - rupress.org
Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune
and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). We …
and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). We …
Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme
PLCγ enzymes are autoinhibited in resting cells and form key components of intracellular
signaling that are also linked to disease development. Insights into physiological and …
signaling that are also linked to disease development. Insights into physiological and …
[HTML][HTML] A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells
C Prawiro, TD Bunney, C Kampyli, H Yaguchi… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background Development of adult T-cell leukemia/lymphoma (ATL) involves human T-cell
leukemia virus type 1 (HTLV-1) infection and accumulation of somatic mutations. The most …
leukemia virus type 1 (HTLV-1) infection and accumulation of somatic mutations. The most …
Purification and characterization of full-length monomeric TEC family kinase, ITK
UM Rathnayake, J Wada, VE Wall, J Jones… - Protein Expression and …, 2025 - Elsevier
An early step in the activation of T cells via the T cell antigen receptor is the phosphorylation
and activation of phospholipase C-γ1 (PLC-γ1) by the TEC family tyrosine kinase, interleukin …
and activation of phospholipase C-γ1 (PLC-γ1) by the TEC family tyrosine kinase, interleukin …
[HTML][HTML] De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects
Phospholipase C isozymes (PLCs) hydrolyze phosphatidylinositol 4, 5-bisphosphate into
inositol 1, 4, 5-trisphosphate and diacylglycerol, important signaling molecules involved in …
inositol 1, 4, 5-trisphosphate and diacylglycerol, important signaling molecules involved in …
[HTML][HTML] 淋巴细胞胞浆蛋白2 的功能及其在恶性肿瘤中的研究进展
陈静， 张莉 - Advances in Clinical Medicine, 2023 - hanspub.org
淋巴细胞胞浆蛋白2 (Lymphocyte cytoplasmic protein 2, LCP2, 也称SLP-76)
参与调控多种免疫细胞的活动, 在T 细胞激活中发挥着重要作用, 介导T 细胞生长发育过程中的多 …
参与调控多种免疫细胞的活动, 在T 细胞激活中发挥着重要作用, 介导T 细胞生长发育过程中的多 …
[图书][B] Mapping T-Cell Signal Integration From Synthetic, Membrane-Associated T-Cell Receptor Agonists
KB Wilhelm - 2022 - search.proquest.com
T-cell receptors (TCRs) recognize sparse pathogenic peptides (p) displayed in major
histocompatibility complex (MHC) proteins on the surface of antigen presenting cells (APCs) …
histocompatibility complex (MHC) proteins on the surface of antigen presenting cells (APCs) …