Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

Objective To examine the effect of the orexinergic blockade with a dual orexin receptor
antagonist (DORA) on experimental models of peripheral and central trigeminal as well as …

Orexin (hypocretin) receptor antagonists stand as a model for the development of targeted
CNS small-molecule therapeutics. The identification of mutations in the gene for the orexin 2 …

Migraine is a common neurological disorder that affects 11% of adults worldwide. This
disease most likely has a neurovascular origin. Migraine with aura (MA) and more common …

Background We wished to explore possible sexual dimorphism in mechanisms sensitizing
or activating meningeal nociceptors that can promote the headache phase of migraine …

Orexin A and B (also named hypocretin 1 and 2) are 33 and 28 amino acid-containing
neuropeptides, respectively, derived from prepro-orexin (prepro-hypocretin) which is …

Orexins including two peptides, orexin‐A and orexin‐B, are produced in the posterior lateral
hypothalamus. Much evidence has indicated that central orexinergic systems play numerous …

Sensitization and activation of trigeminal nociceptors is implicated in prevalent and
debilitating orofacial pain conditions including temporomandibular joint (TMJ) disorders …

SB-334867 has been an important ligand for the study of the orexin 1 (OX1) receptor due to
its high OX1/OX2 selectivity and bioavailability. This ligand however, contains a 2 …