Role of optineurin in the mitochondrial dysfunction: potential implications in neurodegenerative diseases and cancer
R Weil, E Laplantine, S Curic, P Génin - Frontiers in immunology, 2018 - frontiersin.org
Optineurin (Optn) is a 577 aa protein encoded by the Optn gene. Mutations of Optn are
associated with normal tension glaucoma and amyotrophic lateral sclerosis, and its gene …
associated with normal tension glaucoma and amyotrophic lateral sclerosis, and its gene …
The emerging role for Cullin 4 family of E3 ligases in tumorigenesis
As a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much
attention due to its broad regulatory roles under physiological and pathological conditions …
attention due to its broad regulatory roles under physiological and pathological conditions …
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis
Subcellular location and activation of Tank Binding Kinase 1 (TBK1) govern precise
progression through mitosis. Either loss of activated TBK1 or its sequestration from the …
progression through mitosis. Either loss of activated TBK1 or its sequestration from the …
Targeting TANK-binding kinase 1 (TBK1) in cancer
Introduction TANK-binding kinase 1 (TBK1) is a Ser/Thr kinase with a central role in
coordinating the cellular response to invading pathogens and regulating key inflammatory …
coordinating the cellular response to invading pathogens and regulating key inflammatory …
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation
Mutations in the TBK1 (TANK binding kinase 1) gene are causally linked to amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 phosphorylates the cargo …
lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 phosphorylates the cargo …
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery
S Xiang, S Song, H Tang, JB Smaill, A Wang, H Xie… - Drug discovery today, 2021 - Elsevier
Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and
progression of many diseases, such as inflammation, autoimmune diseases, metabolic …
progression of many diseases, such as inflammation, autoimmune diseases, metabolic …
Discovery of BAY-985, a highly selective TBK1/IKKε inhibitor
J Lefranc, VK Schulze, RC Hillig, H Briem… - Journal of Medicinal …, 2019 - ACS Publications
The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKε are
noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These …
noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These …
Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities
Abstract TANK-binding kinase 1 (TBK1) plays a fundamental role in regulating the cellular
responses and controlling several signaling cascades. It regulates inflammatory, interferon …
responses and controlling several signaling cascades. It regulates inflammatory, interferon …
Tumor-intrinsic CDC42BPB confers resistance to anti-PD-1 immune checkpoint blockade in breast cancer
Immune checkpoint blockade has been used to treat breast cancer, but the clinical
responses remain relatively poor. We have used the CRISPR-Cas9 kinome knockout library …
responses remain relatively poor. We have used the CRISPR-Cas9 kinome knockout library …
In silico insights: QSAR modeling of TBK1 kinase inhibitors for enhanced drug discovery
TBK1, or TANK-binding kinase 1, is an enzyme that functions as a serine/threonine protein
kinase. It plays a crucial role in various cellular processes, including the innate immune …
kinase. It plays a crucial role in various cellular processes, including the innate immune …