Treg cells are critical regulators of immune homeostasis, and environment-driven Treg cell
differentiation into effector (e) Treg cells is crucial for optimal functioning. However, human …

Chia (Salvia hispanica) is an emerging crop considered a functional food containing
important substances with multiple potential applications. However, the molecular basis of …

Psoriasis is a chronic inflammatory skin disorder. Although it has been studied extensively,
the molecular mechanisms driving the disease remain unclear. In this study, we utilized a …

The proteostasis network (PN) is a collection of protein folding and degradation pathways
that spans cellular compartments and acts to preserve the integrity of the proteome. The …

Introduction Upon birth, a hitherto naïve immune system is confronted with a plethora of
microbial antigens due to intestinal bacterial colonization. To prevent excessive …

Collagen expression and structure in the tumour microenvironment are associated with
tumour development and therapy response. Leukocyte-associated immunoglobulin-like …

The mucosal immune system is implicated in the etiology and progression of inflammatory
bowel diseases. The lamina propria and epithelium of the gut mucosa constitute two …

Acquired resistance to MAPK inhibitors limits the clinical efficacy in melanoma treatment. We
and others have recently shown that BRAF inhibitor (BRAFi)-resistant melanoma cells can …

Transcription factors play important roles in maintaining normal biological function, and their
dysregulation can lead to the development of diseases. Identifying candidate transcription …

Objective Oral squamous cell carcinoma (OSCC) counts for 90% of pathology in oral cavity
cancer. Oral leukoplakia is the most frequent type of pre-invasive lesion leading to OSCC …