Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Maintenance of a constant cell volume in response to extracellular or intracellular osmotic
changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Ca 2+-permeable channels that are involved in the responses of mammalian cells to
changes in extracellular osmolarity have not been characterized at the molecular level. Here …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

We have studied activation by phorbol derivatives of TRPV4 channels, the human VRL-2,
and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the …

Cells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as
during cell division, growth, migration and cell death. Mammalian cells adjust their volume …

Functional and molecular analysis of glial voltage-and ligand-gated ion channels underwent
tremendous boost over the last 15 years. The traditional image of the glial cell as a passive …