Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino
terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a
group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that …

The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host
response to infection by microbial pathogens, by orchestrating the innate and acquired host …

Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us
huge amounts of data on their expression, functions and structures. We know much about …

Oral cancer is the eleventh most common cancer globally, with well-established major risk
factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types …

Infectious etiologies for certain human cancers have long been suggested by
epidemiological studies and studies with experimental animals. Important support for this …

Abstract Background The Nuclear Factor kappaB (NF-kB) family consists of transcription
factors that play a complex and essential role in the regulation of immune responses and …

Curcumin (diferuloyl methane), the major yellow pigment from the rhizomes of turmeric
(Curcuma longa Linn), has anticancer properties. Infection with high‐risk human …