Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

The inability to scalably and precisely measure the activity of developmental cis-regulatory
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …

Feature selection facilitates uncertainty disposal and information mining, and it has received
widespread research interests. Divergence-based fuzzy rough sets (Div-FRSs), a new kind …

The cerebral cortex—the brain's covering and largest region—has increased in size and
complexity in humans and supports higher cognitive functions such as language and …

Comparative studies of hominids have long sought to identify mutational events that shaped
the evolution of the human nervous system. However, functional genetic differences are …

The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …

Neocortex expansion during evolution is linked to higher numbers of neurons, which are
thought to result from increased proliferative capacity and neurogenic potential of basal …

Cataloging the diverse cellular architecture of the primate brain is crucial for understanding
cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell …