Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

Numerous studies have reported that individuals can simultaneously harbor multiple distinct
strains of Mycobacterium tuberculosis. To date, there has been limited discussion of the …

Advances in modern sequencing technologies allow us to generate sufficient data to
analyze hundreds of bacterial genomes from a single machine in a single day. This potential …

Background Whole genome sequencing (WGS) is becoming an important part of
epidemiological investigations of infectious diseases due to greater resolution and cost …

Background Nearly two decades after completion of the genome sequence of
Mycobacterium tuberculosis (MTB), and with the advent of next generation sequencing …

Background Repeated culture reduces within-sample Mycobacterium tuberculosis genetic
diversity due to selection of clones suited to growth in culture and/or random loss of …

Mycobacterium tuberculosis remains a leading cause of death worldwide, especially among
individuals infected with HIV. Whereas phylogenetic analysis has revealed M. tuberculosis …

Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in
Mycobacterium tuberculosis bacilli within a single patient. This microbiological …

Tuberculosis (TB) is a leading cause of death globally. Understanding the population
dynamics of TB's causative agent Mycobacterium tuberculosis complex (Mtbc) in-host is vital …

Molecular and phylogeographic studies have led to the definition within the Mycobacterium
tuberculosis complex (MTBC) of a number of geotypes and ecotypes showing a preferential …