[HTML][HTML] Human-specific epigenomic states in spermatogenesis

C Liao, BW Walters, M DiStasio, BJ Lesch - Computational and Structural …, 2024 - Elsevier
Infertility is becoming increasingly common, affecting one in six people globally. Half of
these cases can be attributed to male factors, many driven by abnormalities in the process of …

[HTML][HTML] Characterization of long-term ex vivo expansion of tree shrew spermatogonial stem cells

C Li, R Bi, L Wang, YH Ma, YG Yao… - Zoological Research, 2023 - ncbi.nlm.nih.gov
Tree shrews (Tupaia belangeri chinensis) share a close relationship to primates and have
been widely used in biomedical research. We previously established a spermatogonial stem …

Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice

D Zhou, H Wu, L Wang, X Wang, S Tang, Y Zhou… - Journal of Genetics and …, 2024 - Elsevier
Oligoasthenoteratozoospermia is an important factor affecting male fertility and has been
found to be associated with genetic factors. However, there are still a proportion of …

Deleterious variants in X-linked RHOXF1 cause male infertility with oligo- and azoospermia

S Yi, W Wang, L Su, L Meng, Y Li, C Tan… - Molecular Human …, 2024 - academic.oup.com
Oligozoospermia and azoospermia are two common phenotypes of male infertility
characterized by massive sperm defects owing to failure of spermatogenesis. The …

ZMYND12 serves as an IDAd subunit that is essential for sperm motility in mice

C Wang, Q Xie, X Xia, C Zhang, S Jiang, S Wang… - 2024 - researchsquare.com
Inner dynein arms (IDAs) are formed from a protein complex that is essential for appropriate
flagellar bending and beating. IDA defects have previously been linked to the incidence of …

Identification of a DLG3 stop mutation in the MRX20 family

J Huyghebaert, L Mateiu, E Elinck… - European Journal of …, 2024 - nature.com
Here, we identified the causal mutation in the MRX20 family, one of the larger X-linked
pedigrees that have been described in which no gene had been identified up till now. In …

[引用][C] PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility

C Liu, F Zhang - Science China Life Sciences, 2023 - Springer
Small noncoding RNAs (snRNAs) such as short interfering RNAs (siRNAs), microRNAs
(miRNAs), and PIWI-interacting RNAs (piRNAs) play important roles in diverse cellular …