Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post‐genome era

T Raudsepp, CJ Finno, RR Bellone… - Animal …, 2019 - Wiley Online Library
The horse reference genome from the Thoroughbred mare Twilight has been available for a
decade and, together with advances in genomics technologies, has led to unparalleled …

Ancient genomes revisit the ancestry of domestic and Przewalski's horses

C Gaunitz, A Fages, K Hanghøj, A Albrechtsen, N Khan… - Science, 2018 - science.org
The Eneolithic Botai culture of the Central Asian steppes provides the earliest
archaeological evidence for horse husbandry,~ 5500 years ago, but the exact nature of early …

Genetics of Thoroughbred racehorse performance

E Bailey, JL Petersen… - Annual Review of Animal …, 2022 - annualreviews.org
Thoroughbred horses have been selected for racing performance for more than 400 years.
Despite continued selection, race times have not improved significantly during the past 60 …

Ancient genomic changes associated with domestication of the horse

P Librado, C Gamba, C Gaunitz, C Der Sarkissian… - Science, 2017 - science.org
The genomic changes underlying both early and late stages of horse domestication remain
largely unknown. We examined the genomes of 14 early domestic horses from the Bronze …

Prehistoric genomes reveal the genetic foundation and cost of horse domestication

M Schubert, H Jónsson, D Chang… - Proceedings of the …, 2014 - National Acad Sciences
The domestication of the horse∼ 5.5 kya and the emergence of mounted riding, chariotry,
and cavalry dramatically transformed human civilization. However, the genetics underlying …

Genome-wide analysis reveals selection for important traits in domestic horse breeds

JL Petersen, JR Mickelson, AK Rendahl… - PLoS …, 2013 - journals.plos.org
Intense selective pressures applied over short evolutionary time have resulted in
homogeneity within, but substantial variation among, horse breeds. Utilizing this population …

The genetic origin and history of speed in the Thoroughbred racehorse

MA Bower, BA McGivney, MG Campana, J Gu… - Nature …, 2012 - nature.com
Selective breeding for speed in the racehorse has resulted in an unusually high frequency of
the C-variant (g. 66493737C/T) at the myostatin gene (MSTN) in cohorts of the …

The evolutionary and historical foundation of the modern horse: Lessons from ancient genomics

L Orlando - Annual Review of Genetics, 2020 - annualreviews.org
The domestication of the horse some 5,500 years ago followed those of dogs, sheep, goats,
cattle, and pigs by∼ 2,500–10,000 years. By providing fast transportation and transforming …

Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses

T Tozaki, A Ohnuma, M Kikuchi, T Ishige, H Kakoi… - Scientific reports, 2021 - nature.com
The Thoroughbred breed was formed by crossing Oriental horse breeds and British native
horses and is currently used in horseracing worldwide. In this study, we constructed a single …

Screening for gene doping transgenes in horses via the use of massively parallel sequencing

J Maniego, B Pesko, J Habershon-Butcher, J Huggett… - Gene therapy, 2022 - nature.com
Throughout the history of horse racing, doping techniques to suppress or enhance
performance have expanded to match the technology available. The next frontier in doping …